By Kofi Outlaw

Following in the hallowed steps of popular animated sitcoms, a Family Guy movie seems inevitable—especially now that Fox’s other hot animated property, The Simpsons, has cashed in at the box office. Always the comedian, creator Seth MacFarlane sat down with MTV recently to dish on the likelihood of a Family Guy feature film, and even who he’d like to see play live-action roles of TV’s most depraved family, the Griffins.

“I guess Juliette Lewis would be Meg, David Hyde Pierce would be Stewie,” [MacFarlane] chuckled. “Ann Coulter would be Brian. Let’s see, Rosie O’Donnell would be Peter—She’d do a good job, she’s talented, a multi-faceted entertainer.”

“Who did I leave out?” MacFarlane laughed. “Oh, Chris! Phillip Seymour Hoffman! And of course Lois would be, let’s give it to Kathy Griffin for god’s sakes. She’s paid her dues!”

Of course he is joking, but MacFarlane is enthusiastic about seeing a feature-length Family Guy misadventure reach the silver screen—if proper timing can be worked out between screens big and small:

“At some point, I hope [to make a “Family Guy” movie,] he insisted. “The trick is to find a way to do it and do the series a the same time. That’s almost impossible and I think that’s why it took ‘The Simpsons’ twenty years. Hopefully it’s sooner rather than later.”

Apparently there are no breaks over at the MacFarlane studios. I’m sure that makes for a lot of cramped-hand cartoonists. Still, one must wonder how many hit-or-miss episodes are worth the delay of one glorious film, unchained and free to revel in all the debauchery and phallic jokes that can be rammed into an ‘R’ rating.

In the meantime, rant and tell us your top picks to cast a live-action Family Guy movie.